Additionally, boceprevir may increase serum concentrations of hypericin (the active component of St. John's wort). Schulz, H. U., Schurer, M., Bassler, D., and Weiser, D. Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet. View abstract. Taking one capsule of a specific product that contains St. John's wort and valerian root (Sedariston Concentrate, Aristo Pharma GmbH) by mouth daily for one week, then one or two capsules twice daily for another week, reduces nervousness more than the prescription medication diazepam. View abstract. Pharmacopsychiatry 2001;34:45-9. Maturitas 2007;57:405-14. View abstract. View abstract. Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. View abstract. Avoid combination.Goey 2014, Dolutegravir: St. John's wort may decrease the serum concentration of dolutegravir. View abstract. You should talk with your health care provider for complete information about the risks and benefits of using this product. Taking St. John's wort along with dextromethorphan (Robitussin DM, others) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety. American Association for Cancer Research Annual Meeting, San Francisco, April 2002. View abstract. Life Sci 2002;70:3077-96. Lavie, G., Valentine, F., Levin, B., Mazur, Y., Gallo, G., Lavie, D., Weiner, D., and Meruelo, D. Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. Avoid combination.Istodax June 2013, Serotonin modulators: Serotonin modulators may enhance the adverse/toxic effect of other serotonin modulators. Clin Pharmacol.Ther. View abstract. The lowest minimum bactericidal concentrations (350 mcg/mL) were observed for S. epidermidis, Bacillus subtilis, and C. albicans, and were fairly comparable between the 2 extracts. View abstract. St John's wort may decrease the serum concentration of quetiapine. Chatterjee SS, Bhattacharya SK, Singer A, and et al. CYP3A4 inducers (moderate) may decrease the serum concentration of clarithromycin. View abstract. View abstract. View abstract. 2012;27(2):121-124. Avoid combination.Xarelto July 2011, Romidepsin: St. John's wort may decrease the serum concentration of romidepsin. Hostanska, K., Reichling, J., Bommer, S., Weber, M., and Saller, R. Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. Effect of herbal supplements on cyclosporine blood levels and associated acute rejection. Woelk H. Comparison of St. John's wort and imipramine for treating depression: randomized controlled trial. J Clin Psychopharmacol. Schrader E, Meier B, and Brattstrom A. Hypericum treatment of mild-moderate depression in a placebo-controlled study. Asher GN, Gartlehner G, Gaynes BN, et al. View abstract. Am J Med 2002;112:507-8. View abstract. Harrer, G., Hubner, W. D., and Podzuweit, H. Effectiveness and tolerance of the hypericum extract LI 160 compared to maprotiline: a multicenter double-blind study. St. John's wort also increases serotonin. Some medications for depression also increase the brain chemical serotonin. Br J Dermatol 2000;143:1127-8. Pharmacopsychiatry 1997;30:94-101. But not all St. John's wort combination products seem to be beneficial. J.Oral Pathol.Med. View abstract. Crowe, S. and McKeating, K. Delayed emergence and St. John's wort. Lei HP, Yu XY, Xie HT, et al. J Geriatr Psychiatry Neurol 1994;7 Suppl 1:S12-4. View abstract. A typical dosage would be 1-2 teaspoons of dried St John's wort herb, added to hot water, infused for 10-15 minutes and taken 3 times a day. Taking St. John's wort by mouth does not seem to be effective for treating adults with hepatitis C infection. There are St John's wort products which contain hyperforin as the main active ingredient. Lancet 2000;355:576-7. Dean AJ, Moses GM, Vernon JM. This could increase the effects and side effects of procainamide. A review of the recent advances in its pharmacology. Monitor therapy.Izzo 2016, Methylene blue: Methylene blue may enhance the serotonergic effect of serotonin modulators. Forsch.Komplementmed. Evaluation of chemical stability of St. John's wort commercial extract and some preparations. Tannergren, C., Engman, H., Knutson, L., Hedeland, M., Bondesson, U., and Lennernas, H. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. View abstract. St. John's wort might increase how quickly the liver breaks down some medications. The body breaks down nortriptyline (Pamelor) to get rid of it. Scientific Name(s): Hypericum perforatum L.Common Name(s): Amber touch-and-heal, Esbericum, Goatweed, Gol-raei, Hofariqoun, Hyperforat, Hyperiforce, John's wort, Kira, Klamath weed, LI 160, Millepertuis, Neuroplant, Psychotonin, Rosin rose, Sedariston, St John's wort, St. John's wort, STEI 300, WS 5573, Ze 117. Avoid combination.Tivicay June 2015, Doxorubicin (conventional): St. John's wort may decrease the serum concentration of doxorubicin (conventional). Ann Intern Med 2000;132:743-56. John's wort is often used to treat depression and menopausal symptoms. Early research shows that applying St. John's wort liquid or ointment to the skin decreases the severity and the size of psoriasis patches. Acute neuropathy after exposure to sun in a patient treated with St. John's Wort. View abstract. Avoid combination.Dresser 2003, Ibrance February 2016, Imai 2008, Sugimoto 2001, Wang 2001, Paliperidone: St. John's wort may decrease the serum concentration of paliperidone. This could decrease the effectiveness of nortriptyline (Pamelor). Avoid combination.Xtandi August 2012, Erlotinib: St. John's wort may decrease the serum concentration of erlotinib. Zullino, D. and Borgeat, F. Hypertension induced by St. John's Wort - a case report. Early research shows that taking hypericin, a chemical in St. John's wort, by mouth for up to 3 months might reduce tumor size and improve the survival rate in people with brain tumors. Woelk H, Burkard G, and Grunwald J. Nutzen und Risikobewertung des Hypericum-extraktes LI 160 auf der Basis einer Drug-Monitoring-Studie mit 3250 patienten. A long-term disorder of the large intestines that causes stomach pain (irritable bowel syndrome or IBS). 2011;113(1):84-85. Rash associated with St. John's wort treatment in premenstrual dysphoric disorder. Pajonk, F., Scholber, J., and Fiebich, B. Hypericin-an inhibitor of proteasome function. St. John's wort can also affect serotonin. Butterweck, V., Wall, A., Lieflander-Wulf, U., Winterhoff, H., and Nahrstedt, A. This could lead to serious side effects including heart problems, shivering, and weakness. Prim Care Companion CNS Disord 2013;15(1). J Geriatr.Psychiatry Neurol. Meruelo, D., Lavie, G., and Lavie, D. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Decreased self-administration of ethanol and withdrawal syndrome have been demonstrated in rodents, as well as no increased ethanol intake after periods of deprivation.De Vry 1999, Ebrahimie 2015, Uzbay 2008, Uzbay 2008. St. John's wort might increase how quickly the body breaks down phenytoin. Antimicrob.Agents Chemother. Med J Aust 1998;169:583-6. View abstract. This could cause serious side effects including heart problems, shivering, nausea, headache, and anxiety. Do not take St. John's wort if you are taking cyclosporine (Neoral, Sandimmune). Taking St. John's wort along with some medications that are changed by the liver can decrease the effectiveness of some medications. Other possible rare adverse reactions include induction of mania and effects on male and female reproductive capabilities. Demisch L, Holzl J, Gollnik B, and et al. Contraceptive failure is possible. Clin Pharmacol Ther 2000;67:451-7. Br J Dermatol 2001;144:916-8. Carpenter, S. and Kraus, G. A. Photosensitization is required for inactivation of equine infectious anemia virus by hypericin. The extract can be used alone or in combination with other herbs as a nutritional supplement in a capsule, tablet, liquid, or topical product. Consider therapy modification.Izzo 2016, Russo 2014, Nilotinib: St. John's wort may decrease the serum concentration of nilotinib. View abstract. St. John's wort can increase how quickly the body gets rid of some medications. Taking St. John's wort along with some medications that are broken down by the liver can decrease the effectiveness of your medication. Related Plants. Warfarin (Coumadin) interacts with ST. JOHN'S WORT. View abstract. Anxiety. Pharmacopsychiatry 1997;30 Suppl 2:102-107. Monitor therapy.Abadie 2015, Ailawadhi 2007, Alkhatib 2010, Altman 2007, Asch 1988, Brown 1996, Bush 2006, Das 2008, Davis 2013, Dougherty 2002, Egberts 1997, El-Okdi 2014, Falls 2014, FDA 2016, Filter 2007, Fluoxetine 2004, Gillman 1995, Gillman 2005, Gnanadesigan 2005, Gollapudy 2012, Guo 2009, Hansen 1990, Hillman 2015, Houlihan 2004, Hunter 2006, Insler 1994, Isenberg 2008, John 2007, Karunatilake 2006, Kesavan 1999, Kirschner 2010, Kitson 2005, Lamberg 2014, Lange-Asschenfeldt 2002, Lantz 1998, Larson 2015, Lee 2009, Mahlberg 2004, Marechal 2011, Martinez 2008, Mason 1997, Mateo-Carrasco 2015, Meyer 1981, Mittino 2004, Noble 1992, Ozkardesler 2008, Peacock 2011, Pedavally 2014, Rang 2008, Robles 2015, Rosebraugh 2001, Roy 2003, Shahani 2012, Shakoor 2014, Song 2013, Tashakori 2010, Tissot 2003, Venlafaxine 2004, Vizcaychipi 2007, Zornberg 1991, Osimertinib: St. John's wort may decrease the serum concentration of osimertinib. St John's wort extract (LI 160) in somatoform disorders: results of a placebo-controlled trial. St John's wort is possibly effective for menopausal symptoms, plaque psoriasis, wound healing and somatisation disorder. Interventions included H. perforatum as monotherapy (3 studies) as well as in combination with chaste tree or black cohosh. JAMA 2008;299:2633-41. St. John's wort should be avoided during pregnancy and lactation until further long-term studies demonstrate a lack of toxicity in the developing fetus and breastfeeding infants. View abstract. Monitor therapy.Bosak 2014, Martini 2015, Skelaxin March 2018, Surmaitis 2015, Metformin: St John's wort may decrease the renal clearance of metformin. Rash associated with St. John's wort treatment in premenstrual dysphoric disorder. View abstract. HIV/AIDS. 10-6-2001;145(40):1943-1945. Consider therapy modification.Russo 2014, Idelalisib: St. John's wort may decrease the serum concentration of idelalisib. Anon. Avoid combination.Zydelig July 2014, Ifosfamide: CYP3A4 inducers (moderate) may decrease serum concentrations of the active metabolite(s) of ifosfamide. 3. Gender specificity for neuropathic effects has also been noted in the German Federal Institute for Drugs and Medical Devices. Identification of selective MAO-type-A inhibitors in Hypericum perforatum L. (Hyperforat). The dose of your warfarin (Coumadin) might need to be changed. Potential adverse reactions include GI symptoms (eg, dry mouth, dizziness, constipation) and confusion. 2019;236(2):613-623. 1996;40(9):2087-2093. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum). J Psychopharmacol. Aminolevulinic acid interacts with ST. JOHN'S WORT. View abstract. Ruschitzka F, Meier PJ, Turina M, et al. Pharmacopsychiatry 2001;34:S127-33. Due to the lack of rigorous standardization of product purity and potency in the United States, data were deemed insufficient to recommend a place in therapy for St. John's wort in the treatment of MDD.Qaseem 2016, Based on efficacy in depression, Hypericum extracts have been recommended as appropriate therapy in mild or moderate depression with bipolar disorder as an alternative to standard antidepressant therapy.Andreescu 2008 A trial (N=54) evaluating the efficacy of 900 mg of Hypericum extract daily in adolescents with attention-deficit/hyperactivity disorder and a subsequent systematic review found no difference compared with placebo at 8 weeksSarris 2011, Weber 2008 and no difference using the same dosage in burning mouth syndrome.Sardella 2008 St. John's wort 600 mg/day performed better than placebo in 6 primary outcome measures in patients with somatoform disorders.Müller 2004 Equivocal results have been demonstrated for Hypericum extracts in the management of premenstrual symptoms, which may be reflective of the different dosages used.Hicks 2004, Stevinson 2000 Improvement in total, behavioral, and physical symptoms in women diagnosed with premenstrual syndrome (PMS) has been demonstrated with Hypericum compared to placebo in double-blind RCTs that include a small crossover pilot study (N=36) and a larger prospective trial (N=170).Canning 2010, Ghazanfarpour 2011, Seasonal affective disorder, a type of depression in which symptoms occur in fall/winter and resolve in spring/summer, improved with St. John's wort in combination with light therapy.Martinez 1994 In an open-label trial, statistically but not clinically significant improvements in several target behaviors in 3 young autistic males (19 to 22 years of age) were documented after 4 weeks of St. John's wort 20 mg/day. The naphthodianthrones (hypericin, pseudohypericin) and the phloroglucinols (hyperforin, adhyperforin) are the most characterized.Russo 2014, Naphthodianthrons occur in St. John's wort in concentrations of less than 0.1% to 0.15%. Jiang X, Williams KM, Liauw WS, et al. There is no standard recommended dosage of St John's wort in the UK and it's not currently clear what dosage works best. Lancet Neurol 2002;1:275. Taking St. John's wort along with tramadol (Ultram) might cause too much serotonin in the brain and side effects including confusion, shivering, stiff muscles, and other side effects. View abstract. Consider therapy modification.Supect 2014, Ranolazine: St. John's wort may decrease the serum concentration of ranolazine. Cancer Chemother.Pharmacol 2005;55(5):439-446. Proc Natl Acad Sci U S A 2000;97:7500-2. Jones D. Tourian LT, Margolese H. Possible association of syndrome of Inappropriate secretion of antidiuretic hormone with St. John's wort use. View abstract. Laird RD and Webb M. Psychotic episode during use of St John's wort. Ann Intern Med 1999;130:510-4. View abstract. In the second week, take 300 mg twice a day. Pharmacopsychiatry 1997;30:81-5. Hudson, J. J Geriatr.Psychiatry Neurol. Biochem Pharmacol 10-15-2001;62(8):1059-1070. 2004;10(6):925-932. J Hepatol 2000;33:853-5. Linde K, Mulrow CD. Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum. Arch Dermatol 2001;137:512-3. St John's wort may decrease the serum concentration of irinotecan products. J Nat Prod 2001;664:127-30. View abstract. Benefit in reducing some climacteric symptoms in women with natural menopause has also been demonstrated. View abstract. St. John's wort might not be as effective for more severe cases of depression. Ernst E, Rand JI, Barnes J, Stevinson C. Adverse effects profile of the herbal antidepressant St. John's wort (Hypericum perforatum L.). Avoid combination.Zepatier January 2016, Eliglustat: St. John's wort may decrease the serum concentration of eliglustat. Photochem.Photobiol. Some medications are changed and broken down by the liver. Zhou, C., Tabb, M. M., Sadatrafiei, A., Grun, F., Sun, A., and Blumberg, B. Hyperforin, the active component of St. John's wort, induces IL-8 expression in human intestinal epithelial cells via a MAPK-dependent, NF-kappaB-independent pathway. In 2000, the FDA issued a warning about serious and possibly deadly drug interactions when used with St. John’s Wort. Consider therapy modification.Tradjenta May 2011, Linezolid: Linezolid may enhance the serotonergic effect of serotonin modulators. Tea with St. John's wort during pregnancy. Avoid combination.Bosulif September 2012, Brentuximab vedotin: P-gp/ABCB1 Inducers may decrease the serum concentration of brentuximab vedotin. Jakovljevic V, Popovic M, Mimica-Dukic N, et al. View abstract. But other research shows that taking a St. John's wort extract for 8 weeks does not improve ADHD symptoms in children ages 6-17 years. Grube, B., Walper, A., and Wheatley, D. St. John's Wort extract: efficacy for menopausal symptoms of psychological origin. Consider therapy modification.Ahmed 2001, Alscher 2003, Barone 2000, Barone 2001, Bauer 2003, Breidenbach 2000, Breidenbach 2000, Dresser 2003, Durr 2000, Izzo 2016, Karliova 2000, Mai 2000, Mai 2004, Mandelbaum 2000, Moschella 2001, Ruschitzka 2000, Turton-Weeks 2001, Yue 2000, CYP3A4 substrates: St. John's wort (a CYP3A4 inducer) may increase the metabolism of CYP3A4 substrates and reduce their effectiveness. View abstract. Wentworth JM, Agostini M, Love J, et al. Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial. The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. View abstract. Avoid combination.Cotellic November 2015, Codeine: CYP3A4 inducers (moderate) may decrease serum concentrations of the active metabolite(s) of codeine. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Wood S, Huffman J, Weber N, and et al. Most of these products are standardized to have 0.3% of hypericin. 1. Taking St. John's wort might increase how quickly the body breaks down these medications. Clinical significance of hyperforin for the efficacy of Hypericum extracts on depressive disorders of different severities. View abstract. Effect of Hypericum perforatum (St. John's wort) in major depressive disorder: a randomized controlled trial. Dugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of St. John's wort (hypericum) during pregnancy and lactation. Bove GM. Hypericin and pseudohypericin inhibit a variety of encapsulated viruses, including HIV.Upton 1997, 3-Hydroxy lauric acid obtained from H. perforatum exhibited light-independent, anti-HIV activity in an in vitro experiment.Maury 2009, Clinical trials of St. John's wort use in HIV are limited by the prevalence of interactions between St. John's wort and standard HIV therapy. View abstract. Panijel M. [Treatment of moderately severe anxiety states]. View abstract. Rahimi, R., Nikfar, S., and Abdollahi, M. Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: a meta-analysis. Risk of bias was low across all domains.Thandar 2017 In a small pilot study (N=10), both St. John's wort and vehicle alone significantly improved erythema, scaling, and thickness in plaques of patients with mild psoriasis. Photosensitization may also occur. Sardella, A., Lodi, G., Demarosi, F., Tarozzi, M., Canegallo, L., and Carrassi, A. Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study. Fogle RH, Murphy PA, Westhoff CL, Stanczyk FZ. Avoid combination.Nexavar October 2011, Sunitinib: St. John's wort may decrease the serum concentration of sunitinib. View abstract. Understanding variability with voriconazole using a population pharmacokinetic approach: implications for optimal dosing. View abstract. Phytother Res. Müller WE, Rolli, M., Schafer, C., and Hafner, U. The body breaks down alprazolam (Xanax) to get rid of it. The body breaks down imatinib to get rid of it. Nortriptyline (Pamelor) interacts with ST. JOHN'S WORT. Saint John's wort. Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with ST. JOHN'S WORT. Avoid combination.Braftovi June 2018, Enzalutamide: St. John's wort may decrease the serum concentration of enzalutamide. A randomized double-blind multicenter clinical trial. It’s usually taken in divided doses (300 mg three times daily or 600 mg twice daily). Gender differences in the dermal expression of interleukins may be involved in this differential response.Hohmann 2016 An interaction of constituents, as found in the whole plant, has been shown to reduce the toxicity of hypericum extracts.Hammer 2014, Long-term treatment (up to 21 days) with St. John's wort significantly increased 2-hour plasma glucose levels (by approximately 40%), total glucose AUC (by 18%), and incremental blood glucose AUC (by 48%) in 10 healthy men. Clin Pharm Ther 2001;69:P86. Paroxetine (Paxil) interacts with ST. JOHN'S WORT. View abstract. View abstract. 1994;60(4):329-332. Mai I, Bauer S, Krueger H, et al. View abstract. St. John's wort may decrease the serum concentration of carisoprodol. This could lead to increased effects and side effects of fexofenadine (Allegra). Hazardous pharmacokinetic interaction of Saint John's wort (Hypericum perforatum) with the immunosuppressant cyclosporin. Ann Pharmacother 2000;34:1013-6. Physico-chemical interactions between extracts of Hypericum perforatum L. and drugs. Dona, M., Dell'Aica, I., Pezzato, E., Sartor, L., Calabrese, F., Della, Barbera M., Donella-Deana, A., Appendino, G., Borsarini, A., Caniato, R., and Garbisa, S. Hyperforin inhibits cancer invasion and metastasis. Adverse reactions to St John's Wort. Rayburn WF, Gonzalez CL, Christensen HD, Stewart JD. Avoid combination.Ixempra May 2010, Ketamine (oral): St. John's wort may decrease the serum concentration of ketamine (oral). Monitor therapy.Drucker 2011, Lankerani 2004, Naldi 1999, Visudyne June 2012, Vincristine (liposomal): St. John's wort may decrease the serum concentration of vincristine (liposomal). Schakau D, Hiller K, Schultz-Zehden W, and et al. St. John's wort can also increase serotonin. Davidson, J. R. and Connor, K. M. St. John's wort in generalized anxiety disorder: three case reports. View abstract. View abstract. A better treatment for depression? This could result in serotonin syndrome. Brockmoller J, Reum T, Bauer S, et al. View abstract. These changes were determined to be clinically insignificant.Jackson 2014, Bortezomib: St. John's wort may decrease the serum concentration of bortezomib. Bernd A, Ramirez-Bosca A, Kippenberger S, and et al. Avoid combination.Kisqali March 2017, Rivaroxaban: St. John's wort may decrease the serum concentration of rivaroxaban. Chatterjee SS, Noldner M, Koch E, Erdelmeier C. Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility. According to Old English phonology, ‘Wort’ is a word for plant. View abstract. Psychopharmacology (Berl) 2002;164:294-300. 2008;(4):CD000448. Consider therapy modification.Gilotrif November 2013, Aminolevulinic acid (systemic): Photosensitizing agents may enhance the photosensitizing effect of aminolevulinic acid (systemic). Melzer, J., Brignoli, R., Keck, M. E., and Saller, R. A hypericum extract in the treatment of depressive symptoms in outpatients: an open study. Clin Pharmacol Ther 2000;67:159, abstract PIII-69. View abstract. Hicks, S. M., Walker, A. F., Gallagher, J., Middleton, R. W., and Wright, J. Consider therapy modification.Izzo 2016, Johne 2002, Ulipristal: St. John's wort may decrease the serum concentration of ulipristal. View abstract. View abstract. Life Sci 2000;66:PL 133-9. Avoid combination. St. John's wort can decrease the effects of reserpine. Clin Pharmacol Ther 2000;67:130, abstract PII-64. Dresser, G. K., Schwarz, U. I., Wilkinson, G. R., and Kim, R. B. Brain Inj 2002;16:359-67. To fight alcoholism, drink a cup of this tea right after breakfast & dinner daily for about one month or more. However, other research shows that taking St. John's wort does not reduce nervousness or other PMS symptoms. Australas.J.Dermatol. Procainamide interacts with ST. JOHN'S WORT. View abstract. View abstract. Consider therapy modification.Azilect May 2014, Dingemanse 1996, Duval 2013, Emsam March 2015, Fernandes 2011, Garcia-Monco 1995, Gitlin 1997, Hilli 2009, Hinds 2000, Jermain 1992, Laine 1997, Lefebvre 1995, Montastruc 1993, Panisset 2015, Richard 1997, Ritter 1997, Smith 2015, Suchowsersky 1990, Toyama 1994, Waters 1994, Wu 2009, Xadago March 2017, Zelapar July 2014, Zomberg 1991, Antipsychotic agents: Serotonin modulators may enhance the adverse/toxic effect of antipsychotic agents. Suspected withdrawal syndrome after cessation of St. John's wort. View abstract. View abstract. Catalytic inhibition of human DNA topoisomerase II alpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum). After 4 weeks, the topical H. perforatum cream significantly improved the intensity of eczema (ie, erythema, papulation, crust, excoriation, lichenification, scaling) as well as reduced S. aureus skin colonization compared to placebo. Obach RS. BMJ 2000;321:536-9. View abstract. St. John's wort might increase the breakdown and decrease the effectiveness of warfarin (Coumadin). Avoid combination.Harvoni October 2014, Linagliptin: P-gp/ABCB1 inducers may decrease the serum concentration of linagliptin. View abstract. AIDS Research and Human Retroviruses 1992;8(11):1929-1936. A., Tobia, A. J., Cabana, B. E., Stillerman, C. B., Forsyth, P. A., Appley, A. J., Spence, A. M., Hinton, D. R., and Chen, T. C. A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. Discuss your plans with your doctor. Avoid combination.Harvoni November 2015, Sovaldi December 2013, Sonidegib: CYP3A4 inducers (moderate) may decrease the serum concentration of sonidegib. J Clin Psychopharmacol 2001;21(6):635-636. Available for Android and iOS devices. Pharmacopsychiatry 1998;31 Suppl 1:22-29. This could result in serotonin syndrome. Benefit in reducing some climacteric symptoms in women with natural menopause has also been demonstrated. Miller LG. Giuggioli D, Lumetti F, Spinella A, et al. View abstract. Schempp CM, Muller K, Winghofer B, et al. Peltoniemi MA, Saari TI, Hagelberg NM, et al. View abstract. Roby CA, Anderson GD, Kantor E, et al. Di, Matteo, V, Di Giovanni, G., Di Mascio, M., and Esposito, E. Effect of acute administration of hypericum perforatum-CO2 extract on dopamine and serotonin release in the rat central nervous system. B., and Towers, G. H. Antiviral activity of the photoactive plant pigment hypericin. Market C, Kastner IM, Hellwig, et al. The body breaks down tacrolimus (Prograf, Protopic) to get rid of it. Schwarz UI, Buschel B, Kirch W. Unwanted pregnancy on self-medication with St John's wort despite hormonal contraception. Extreme tiredness (chronic fatigue syndrome). Shelton RC, Keller MB, Gelenberg A, et al. Clin Pharmacol Ther 1999;66:338-45. Phenytoin (Dilantin) interacts with ST. JOHN'S WORT. Avoid combination.Jalloh 2017, Stribild August 2012, Irinotecan products: St. John's wort may diminish the therapeutic effect of irinotecan. View abstract. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. … View abstract. St. John's wort 300mg 3 times daily for 3-4 months has been used. View abstract. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Kasper, S. Treatment of seasonal affective disorder (SAD) with hypericum extract. Al-Akoum, M., Maunsell, E., Verreault, R., Provencher, L., Otis, H., and Dodin, S. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Acta Gastroenterol.Belg. Koupparis, L. S. Harmless herbs: a cause for concern? View abstract. Specifically, the risk of serotonin syndrome or serotonin toxicity may be increased. View abstract. Monitor therapy.Boyer 2005, Clark 2006, DeBellis 2005, Flanagan 2013, Lavery 2001, Lawrence 2006, Sivextro June 2014, Wigen 2002, Telaprevir: St. John's wort may decrease the serum concentration of telaprevir. Int.Clin.Psychopharmacol. J Altern Complement Med 2010;16:113-7. Planta Med 1984;50(3):272-274. Simmer it for 5 minutes and then strain the tea. Seasonal variation in hypericin content of Hypericum perforatum L. (St. John's Wort). Irinotecan (Camptosar) interacts with ST. JOHN'S WORT. Melatonin in feverfew and other medicinal plants. View abstract. Black cohosh and St. John's wort for climacteric complaints: a randomized trial. Although not all side effects are known, St. John's wort is thought to be likely safe when taken by an adult for up to 12 weeks, or by a child age 6-17 for up to 8 weeks. Phytochemistry 2001;56:437-41. J Clin Psychiatry 2003;64(8):966-968. Application of St. John's wort resulted in greater reduction in erythema scores, scaling scores, and thickness scores, with improvement in scaling being the most pronounced; on a 3-point scale, a mean difference of –1.8 and –0.3 was observed for treatment and vehicle, respectively. Avoid combination.Reyataz June 2014, Axitinib: St. John's wort may decrease the serum concentration of axitinib. Emotional distressed caused by extreme focus on a physical symptom (somatic symptom disorder). The significance of "nonsignificance" in randomized controlled studies: a discussion inspired by a double-blinded study on St. John's wort (Hypericum perforatum L.) for premenstrual symptoms. Of theophylline in healthy subjects Inappropriate secretion of antidiuretic hormone with St. John 's wort may decrease serum. Acts by induction of apoptosis states and parts of Canada serotonin uptake by elevating free intracellular Na+1,! Relates to an herbal, Vitamin K antagonists flower petals have black yellow... Oxycodone: St. John 's wort may decrease the serum concentration of Bortezomib combination.Zepatier January 2016, Russo 2014 Zhao! R. B risks of Long Term St. Johns wort use st john's wort tea dosage, inhibitors, and et al or! Ther 2003 ; 55:203-11.. View abstract 0.3 % of hypericin ( the active monomethyl auristatin E ( )... Walter G. Hypericum perforatum extracts AUC of boceprevir and St. John 's wort is an aggressive weed that grows the... 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